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How Chronic Stress Predisposes Brain to Mental Illness

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By Robert Sanders, UC Berkeley News

University of California, Berkeley, researchers have shown that chronic stress generates long-term changes in the brain that may explain why people suffering chronic stress are prone to mental problems such as anxiety and mood disorders later in life.

Their findings could lead to new therapies to reduce the risk of developing mental illness after stressful events.

Doctors know that people with stress-related illnesses, such as post-traumatic stress disorder (PTSD), have abnormalities in the brain, including differences in the amount of gray matter versus white matter.

Gray matter consists mostly of cells – neurons, which store and process information, and support cells called glia – while white matter is comprised of axons, which create a network of fibers that interconnect neurons. White matter gets its name from the white, fatty myelin sheath that surrounds the axons and speeds the flow of electrical signals from cell to cell.

How chronic stress creates these long-lasting changes in brain structure is a mystery that researchers are only now beginning to unravel.

In a series of experiments, Daniela Kaufer, UC Berkeley associate professor of integrative biology, and her colleagues, including graduate students Sundari Chetty and Aaron Freidman, discovered that chronic stress generates more myelin-producing cells and fewer neurons than normal.

This results in an excess of myelin – and thus, white matter – in some areas of the brain, which disrupts the delicate balance and timing of communication within the brain.

“We studied only one part of the brain, the hippocampus, but our findings could provide insight into how white matter is changing in conditions such as schizophrenia, autism, depression, suicide, ADHD and PTSD,” she said.

The hippocampus regulates memory and emotions, and plays a role in various emotional disorders.

Kaufer and her colleagues published their findings in the Feb. 11 issue of the journal Molecular Psychiatry.

Kaufer’s findings suggest a mechanism that may explain some changes in brain connectivity in people with PTSD, for example. One can imagine, she said, that PTSD patients could develop a stronger connectivity between the hippocampus and the amygdala – the seat of the brain’s fight or flight response – and lower than normal connectivity between the hippocampus and prefrontal cortex, which moderates our responses.

“You can imagine that if your amygdala and hippocampus are better connected, that could mean that your fear responses are much quicker, which is something you see in stress survivors,” she said. “On the other hand, if your connections are not so good to the prefrontal cortex, your ability to shut down responses is impaired. So, when you are in a stressful situation, the inhibitory pathways from the prefrontal cortex telling you not to get stressed don’t work as well as the amygdala shouting to the hippocampus, ‘This is terrible!’ You have a much bigger response than you should.”

She is involved in a study to test this hypothesis in PTSD patients, and continues to study brain changes in rodents subjected to chronic stress or to adverse environments in early life.

Kaufer’s lab, which conducts research on the molecular and cellular effects of acute and chronic stress, focused in this study on neural stem cells in the hippocampus of the brains of adult rats. These stem cells were previously thought to mature only into neurons or a type of glial cell called an astrocyte. The researchers found, however, that chronic stress also made stem cells in the hippocampus mature into another type of glial cell called an oligodendrocyte, which produces the myelin that sheaths nerve cells.

The finding, which they demonstrated in rats and cultured rat brain cells, suggests a key role for oligodendrocytes in long-term and perhaps permanent changes in the brain that could set the stage for later mental problems.

Oligodendrocytes also help form synapses – sites where one cell talks to another – and help control the growth pathway of axons, which make those synapse connections.

The fact that chronic stress also decreases the number of stem cells that mature into neurons could provide an explanation for how chronic stress also affects learning and memory, she said.

 

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Bay Area

Rich Lyons, Longtime Campus Business, Innovation Leader, Will Be UC Berkeley’s Next Chancellor

Rich Lyons, an established economist, former dean of the Haas School of Business and the campus’s current leader for innovation and entrepreneurship, will become the next chancellor at the University of California, Berkeley, the UC Board of Regents announced on April 10.

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Rich Lyons is the first UC Berkeley undergraduate alumnus since 1930 to become the campus's top leader. Photo by Keegan Houser/UC Berkeley.
Rich Lyons is the first UC Berkeley undergraduate alumnus since 1930 to become the campus's top leader. Photo by Keegan Houser/UC Berkeley.

By Jason Pohl

Rich Lyons, an established economist, former dean of the Haas School of Business and the campus’s current leader for innovation and entrepreneurship, will become the next chancellor at the University of California, Berkeley, the UC Board of Regents announced on April 10.

The board’s unanimous confirmation makes Lyons, 63, the first UC Berkeley undergraduate alumnus since 1930 to become the campus’s top leader. In an interview this week, Lyons said he credits his Berkeley roots and his campus mentors with encouraging him to ask big questions, advance institutional culture and enhance public education — all priorities of his for the years to come.

Lyons, who will be Berkeley’s 12th chancellor, will succeed Chancellor Carol Christ, who announced last year that she’d step down as chancellor on July 1.

“I am both thrilled and reassured by this excellent choice. In so many ways, Rich embodies Berkeley’s very best attributes, and his dedication to the university’s public mission and values could not be stronger,” Christ said. “I am confident he will bring to the office visionary aspirations for Berkeley’s future that are informed by, and deeply respectful of, our past.”

Rising through the Berkeley ranks

Born in 1961, Lyons grew up in Los Altos in the early days of the Silicon Valley start-up boom.

He attended Berkeley, where he graduated in 1982 with a Bachelor of Science degree in business and finance. Lyons went on to earn his Ph.D. in 1987 in economics from MIT. After six years teaching at Columbia Business School, Lyons returned west, where in 1993 he joined the Berkeley faculty as a professor of economics and finance, specializing in the study of international finance and global exchange rates.

He’s remained on campus since, with one notable exception.

Starting in 2006, Lyons spent two years working at Goldman Sachs as the chief learning officer. It was a period that instilled in him an appreciation for leadership and the importance of organizational culture.

He carried those lessons with him when he returned to campus in 2008 and became the dean of the Haas School of Business.

While dean, Lyons oversaw the construction of Connie & Kevin Chou Hall, a state-of-the-art academic building that opened in 2017 and is celebrated for its sustainability. He also helped establish two new degree programs, linking the business school with both the College of Engineering and the Department of Molecular and Cell Biology.

But it was his creation of four distinct defining leadership principles that spurred a sweeping culture initiative at the school that stands out in the minds of many. Those values — question the status quo, confidence without attitude, students always, and beyond yourself — became a creed of sorts for new students and alumni alike.

Those values are important, Lyons said, because they shape and support the cohesive structure of a strong, connected community — spanning science and technology to the arts and humanities. They also convey the story about what it means to be at Berkeley and to believe in the university’s public mission.

“When we are great as educators, it’s identity-making,” Lyons said. “We’re helping students and others see identities in themselves that they couldn’t see.”

Lyons in January 2020 became Berkeley’s first-ever chief officer of innovation and entrepreneurship.

Building on his research exploring how leaders drive innovation and set behavioral norms and culture, Lyons worked to expand and champion Berkeley’s rich portfolio of innovation and entrepreneurship activities for the benefit of students, faculty, staff, startups and external partners.

It was a major commitment to thinking outside the box, he said. One need only look to the Berkeley Changemaker program that he helped launch in 2020 to see innovation and entrepreneurship in action.

The campuswide program with some 30 courses tells the story of what Berkeley is — the story that members of the Berkeley community can tell long into the future. Berkeley Changemaker started as an idea and its courses quickly became among the most popular academic offerings on campus.

“Over 500 students showed up,” he said. “Why? Because it’s a narrative. It’s not just a name. It’s not just a curriculum. It’s not just a course. It’s a way of living, and it’s a way of living that Berkeley has occupied forever. This idea that there’s got to be a better way to do this, question the status quo.”

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Activism

Oakland’s ‘Green the Church,’ Others, Host a Climate Revival

On April 20, Oakland’s Green The Church California (GTC) and the Center For Food, Faith and Justice will celebrate Earth Day and present a Climate Revival event titled “Growing Healthy Communities From Soil To The Soul” at McGee Avenue Baptist Church at 1640 Stuart St, Berkeley, CA. The day will include inspiring talks, interactive workshops, networking opportunities, and a special panel on Food Sovereignty and Global Food Resilience.

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The revival will take place at McGee Avenue Baptist Church in Berkeley on April 20. Courtesy image.
The revival will take place at McGee Avenue Baptist Church in Berkeley on April 20. Courtesy image.

Growing Healthy Communities from Soil to the Soul in Berkeley

By Y’Anad Burrell

On April 20, Oakland’s Green The Church California (GTC) and the Center For Food, Faith and Justice will celebrate Earth Day and present a Climate Revival event titled “Growing Healthy Communities From Soil To The Soul” at McGee Avenue Baptist Church at 1640 Stuart St, Berkeley, CA,

The day will include inspiring talks, interactive workshops, networking opportunities, and a special panel on Food Sovereignty and Global Food Resilience.

The keynote speaker is Rev. Danté R. Quick, PhD, senior pastor of First Baptist Church of Lincoln Gardens in Somerset, N.J. Quick is well known in the Bay Area, having served for more than 10 years as pastor of Friendship Missionary Baptist Church in Vallejo, CA.

Green The Church, founded in 2010 by Rev. Dr. Ambrose Carroll, Sr., and headquartered in Oakland, helps galvanize Black churches and their local communities and leaders to address issues critical to populations historically disengaged from conversations around pollution and health, climate change, and sustainability and energy efficiency.

The organization collaborates with major environmental, sustainability, food security, faith, and community-based non-profit organizations, and is committed to “creation justice”—care and justice for God’s people and the planet—and building the Beloved Community.

Environmental justice has long been a pressing concern for communities of color who bear the brunt of pollution and ecological degradation. Climate change exacerbates these issues, disproportionately impacting vulnerable communities. Recognizing this urgency, Black churches across the country are taking action.

With deep roots in the African American community and its commitment to social justice, the Black Church has become an essential advocate for sustainable practices and policies.

Over the past 14 years, in a powerful collaboration with significant environmental, sustainability, food security, faith, and community-based non-profit organizations, GTC has created a cadre of Black churches engaging in the environmental justice, climate, and sustainability movement.

GTC presently works with more than 1,000 pastors and congregations across the U.S., and groups in the Bahamas, Ghana, Nigeria, and the UK, showing that we can make a difference together.

The partnership between environmental justice advocates and the Black Church extends beyond individual congregations. Green The Church provides resources and support for faith communities seeking to address climate change and promote environmental justice.

Through collaboration, initiatives such as energy efficiency programs, solar installations, and environmental education have been implemented in Black churches nationwide. These efforts reduce the carbon footprint and save money on energy bills, benefiting the congregations and their communities.

The involvement of the Black Church in the fight against climate change is not just a participation, it’s a powerful message that galvanizes action across communities.

By integrating environmental justice into their ministry, Black churches are demonstrating that addressing climate change is not only a matter of science but also of social and moral responsibility, inspiring change at a grassroots level.

For more information, go to: www.greenthechurch.org.

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Activism

Who are the Alameda County District 4 Supervisor Candidates’ Top Campaign Contributors?

Below, we’ve listed each candidate’s 10 highest campaign contributors. For Miley, two of his top campaign donors also bought their own advertisements to support him and/or oppose Esteen through independent expenditures. Such expenditures, though separate from campaign donations, are also public record, and we listed them. Additionally, the National Organization of Realtors has spent about $70,500 on their own independent expenditures to support Miley.

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Jennifer Esteen. (Campaign photo) and Supervisor Nate Miley. (Official photo).
Jennifer Esteen. (Campaign photo) and Supervisor Nate Miley. (Official photo).

By Zack Haber

Nate Miley, who has served on Alameda County’s Board of Supervisors since 2000, is running for reelection to the District 4 supervisor seat.

Jennifer Esteen, a nurse and activist, is seeking to unseat him and become one of the five members of the powerful board that sets the county’s budget, governs its unincorporated areas, and oversees the sheriff, Alameda Health System, and mental health system.

District 4 includes most of East Oakland’s hills and flatlands beyond Fruitvale, part of Pleasanton and unincorporated areas south of San Leandro like Ashland and Castro Valley.

Voting is open and will remain open until March 5.

In California, campaign donations of $100 or more are public record. The records show that Miley has received about $550,000 in total campaign donations since he won the previous District 4 election in March 2020. Esteen has raised about $255,000 in total campaign donations since she started collecting them last July. All figures are accurate through Feb. 20.

While Miley has raised more money, Esteen has received donations from more sources. Miley received donations of $100 or more from 439 different sources. Esteen received such donations from 507 different sources.

Below, we’ve listed each candidate’s 10 highest campaign contributors. For Miley, two of his top campaign donors also bought their own advertisements to support him and/or oppose Esteen through independent expenditures. Such expenditures, though separate from campaign donations, are also public record, and we listed them. Additionally, the National Organization of Realtors has spent about $70,500 on their own independent expenditures to support Miley.

Nate Miley’s top campaign contributors:

The California Apartment Association, a trade group representing landlords and investors in California’s rental housing business, has spent about $129,500 supporting Miley’s election bid through about $59,500 in ads against Esteen$55,000 in ads supporting Miley, and $15,000 in campaign donations.

The independent expenditure committee Preserve Agriculture in Alameda County has spent about $46,025 supporting Miley through about $27,200 in their own ads, and $18,825 in donations to his campaign. Preserve Agriculture has supported reelection efforts for former Alameda County DA Nancy O’Malley, and Sheriff Greg Ahern, a republican. It’s received funding from ChevronPG&E, and a the California Apartment Association.

Organizations associated with the Laborers’ International Union of North America, or LiUNA, have donated about $35,000 in total. Construction and General Laborers Local 304, a local chapter of the union representing which represents over 4,000 workers, donated $20,000.

Laborers Pacific Southwest Regional Organizing Coalition, which represents 70,000 LiUNA members in Arizona, California, Hawaii and New Mexico, donated $15,000.

William ‘Bill’ Crotinger and the East Oakland-based company Argent Materials have donated $26,000. Crotinger is the president and founder of Argent, a concrete and asphalt recycling yard. Argent’s website says it is an eco-friendly company that diverts materials from landfills. In 2018, Argent paid the EPA $27,000 under a settlement for committing Clean Water Act violations.

Michael Morgan of Hayward, owner of We Are Hemp, a marijuana dispensary in Ashland, has donated $21,500.

Alameda County District 1 Supervisor David Haubert has donated $21,250 from his 2024 reelection campaign. He’s running unopposed for the District 1 seat.

SEIU 1021which represents over 60,000 workers in local governments, non-profit agencies, healthcare programs, and schools in Northern California, has donated $20,000.

UA Local 342, which represents around 4,000 pipe trades industry workers in Contra Costa and Alameda counties, donated $20,000.

The union representing the county’s deputy sheriffs, Deputy Sheriff’s Association of Alameda County, has donated $17,000.

Becton Healthcare Resources and its managers have donated $14,625. Becton’s mission statement says it provides “behavioral health management services to organizations and groups that serve the serious and persistent mentally ill population.”

Jennifer Esteen’s top campaign contributors:

Mary Quinn Delaney of Piedmont, founder of Akonadi Foundation, has donated $20,000. Akonadi Foundation gives grants to nonprofit organizations, especially focusing on racial justice organizing,

Bridget Galli of Castro Valley has donated $7,000. Galli is a yoga instructor and a co-owner of Castro Valley Yoga.

Rachel Gelman of Oakland has donated $5,000. Gelman is an activist who has vowed to redistribute her inherited wealth to working class, Indigenous and Black communities.

California Worker Families Party has donated $5,000. The organization’s website describes itself as a “grassroots party for the multiracial working class.”

David Stern of Albany has donated $5,000. Stern is a retired UC Berkeley Professor of Education.

Oakland Rising Committee—a collaborative of racial, economic, and environmental justice organizations—has donated about $3,050.

Fredeke Von Bothmer-Goodyear, an unemployed resident of San Francisco, has donated $2,600.

Robert Britton of Castro Valley has donated $2,500. Britton is retired and worked in the labor movement for decades.

Progressive Era PAC has donated about $2,400. Its mission statement says it “exists to elect governing majorities of leaders in California committed to building a progressive era for people of color.”

East Bay Stonewall Democrats Club has donated $2,250. The club was founded in 1982 to give voice to the East Bay LGBTQIA+ communities.

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