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Study: Women with Mild Memory Problem Worsen Faster Than Men

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ALZHEIMER'S GENDER
LAURAN NEERGAARD, AP Medical Writer

WASHINGTON (AP) — Older women with mild memory impairment worsened about twice as fast as men, researchers reported Tuesday, part of an effort to unravel why women are especially hard-hit by Alzheimer’s.

Nearly two-thirds of Americans with Alzheimer’s are women.

At age 65, seemingly healthy women have about a 1 in 6 chance of developing Alzheimer’s during the rest of their lives, compared with a 1 in 11 chance for men. Scientists once thought the disparity was just because women tend to live longer — but there’s increasing agreement that something else makes women more vulnerable.

“Women are really at the epicenter of the Alzheimer’s disease crisis,” said Dr. Kristine Yaffe of the University of California, San Francisco. “We don’t really understand what this is all about.”

A series of studies presented Tuesday at the Alzheimer’s Association International Conference uncovered signs of that vulnerability well before Alzheimer’s symptoms hit.

First, Duke University researchers compared nearly 400 men and women with mild cognitive impairment, early memory changes that don’t interfere with everyday activities but that mark an increased risk for developing Alzheimer’s. They measured these people’s cognitive abilities over an average of four years and as long as eight years for some participants.

The men’s scores on an in-depth test of memory and thinking skills declined a point a year while the women’s scores dropped by two points a year.

Age, education levels and even whether people carried the ApoE-4 gene that increases the risk of late-in-life Alzheimer’s couldn’t account for the difference, said Duke medical student Katherine Lin, who coauthored the study with Duke psychiatry professor Dr. P. Murali Doraiswamy. The study wasn’t large or long enough to tell if women were more at risk for progressing to full dementia.

Nor could it explain why the women declined faster, but the researchers said larger Alzheimer’s prevention studies should start analyzing gender differences for more clues. And two other studies presented Tuesday offered additional hints of differences in women’s brains:

—A sample of 1,000 participants in the large Alzheimer’s Disease Neuroimaging Initiative compared PET scans to see how much of a sticky protein called beta-amyloid was building up in the brains of a variety of men and women, some healthy, some at risk and others with full-blown Alzheimer’s. Amyloid plaques are a hallmark of Alzheimer’s, and growing levels can help indicate who’s at risk before symptoms ever appear.

“Overall, women have more amyloid than men,” even among the cognitively normal group, said Dr. Michael Weiner of the University of California, San Francisco. The study couldn’t explain why, although it didn’t appear due to the risky ApoE-4 gene, which seemed to make a difference for men with Alzheimer’s but not women.

—Some seniors who undergo surgery while knocked out by general anesthesia suffer lasting cognitive problems afterward, often expressed to doctors as, “Grandma was never the same after that operation.” Tuesday, researchers reported that here again, women are at higher risk of getting worse.

Dr. Katie Schenning of the Oregon Health & Science University tracked records of more than 500 participants in two long-term studies of cognitive aging, which included a battery of brain tests. About 180 participants underwent 331 procedures involving general anesthesia.

Over seven years, people who had undergone surgery with general anesthesia declined faster on measures of cognition, their ability to function and even brain shrinkage than people who hadn’t had surgery. But women declined at a significantly faster rate than men, Schenning said.

“It is worth letting our older patients know that they should perhaps talk about this with their practitioner, that this is a possibility and consider whether or not they need to undergo procedures that are considered to be elective,” she said.

Schenning didn’t have amyloid measurements for these people; other studies have suggested that the people most at risk may have brewing cognitive problems already.

The anesthesia alone isn’t the culprit, she cautioned. Indeed, animal research presented Tuesday showed that surgery in general can spur inflammation-causing molecules to cross into the brain and impair how nerve cells communicate.

Together, the studies show how much more research is needed into the Alzheimer’s gender question, said UCSF’s Yaffe, who wasn’t involved in Tuesday’s studies but was part of a recent Alzheimer’s Association meeting to start determining those next steps.

“It’s not just that women are living to be older. There’s something else going on in terms of the biology, the environment, for women compared to men that may make them at greater risk, or if they have some symptoms, change the progression,” Yaffe said.

Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Bay Area

Advocates Hold Rally to “Issue a Citation” to City to Stop Homeless Encampment Sweeps

Advocates in San Francisco held a rally Thursday afternoon in front of City Hall to issue a symbolic citation to Mayor London Breed, urging an immediate end to the sweeps of homeless encampments in the city. “What do we want? Housing! When do we want it? Now!,” the group chanted. The group of allies and advocates originally intended to start their rally off on Jessie Street, where a sweep of an encampment was going to take place around noon. But, the group had to change their plans because the city allegedly heard about the rally and chose to sweep the area earlier in the day.

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San Francisco homelessness advocates held a rally in front of City Hall to issue a symbolic citation to Mayor London Breed to stop sweeping encampments. Photo by Magaly Muñoz.
San Francisco homelessness advocates held a rally in front of City Hall to issue a symbolic citation to Mayor London Breed to stop sweeping encampments. Photo by Magaly Muñoz.

By Magaly Muñoz

Advocates in San Francisco held a rally Thursday afternoon in front of City Hall to issue a symbolic citation to Mayor London Breed, urging an immediate end to the sweeps of homeless encampments in the city.

“What do we want? Housing! When do we want it? Now!,” the group chanted.

The group of allies and advocates originally intended to start their rally off on Jessie Street, where a sweep of an encampment was going to take place around noon. But, the group had to change their plans because the city allegedly heard about the rally and chose to sweep the area earlier in the day.

The streets adjacent to Jessie St., such as Mission and Market St, are lined with multiple encampments and unhoused individuals. Many stand in groups or walk along the streets by themselves.

One member of the group, Leah, said she lived in District 6 and what politicians claim is an “open drug market” area. She criticized the extra funding that has gone to the San Francisco Police Department to “solve homelessness” but no positive results have been shown.

“If giving the police more money actually solved the housing crisis, the homelessness crisis…then it would’ve gotten better, but it has actually just been getting worse and worse as more services for poor people have been cut,” Leah said.

Other speakers said the problem with sweeping and citing people for living on the streets is that the homeless problem is being exacerbated, and it’s ultimately not helping those who are struggling.

In order to help alleviate the problem, advocates have called for expansions to permanent supportive housing, resources and services, housing vouchers, and rent relief for struggling residents.

According to the 2024 Point in Time Count, 8,323 people were experiencing homelessness in San Francisco. A seven percent increase since 2022 where there were 7,754 sheltered and unsheltered homeless individuals.

In her mission to get people off the streets, Mayor Breed has directed city crews to clear encampments more frequently than before. This decision comes after the landmark case, Grants Pass v. Johnson, was overturned by the U.S Supreme Court and cities were given the authority to ban people from camping or sleeping on the streets.

The mayor also instructed city workers to offer transportation tickets to people before offering shelter with the intent that those who are not originally from San Francisco can return to family or friends elsewhere and services can then be used for long-time residents.

A former homeless resident, Yolanda, in attendance at the rally said it was difficult to get off of living on the streets because of the barriers to housing and services.

Yolanda told the Post that she had grown up in the city with her family, but once her father passed away, there was no one to maintain the bills so they had to relocate to Oakland for a few years. She said her family stayed there for a few years before returning to San Francisco.

As she got older, she found herself living on the streets or in temporary shelter. But these shelters would only allow people to stay for a few months at a time and were very restrictive in what people could do, such as leave when they wanted or have guests with them.

After some time, Yolanda and her boyfriend were selected for housing through a housing allocation program, where she still currently lives now. She said they were one of the lucky ones, but others do not get to experience this same fortune.

She shared that at one point in her journey to find a housing placement, there was a 2,000 person waitlist, making it nearly impossible and disheartening for those looking for a roof to put over their heads.

Yolanda said it was unfair to criminalize people for not being able to afford housing, considering the extremely high costs of living in the area.

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Community

Diabetes Continues to Largely Impact Low-Income Black and Brown Communities

Communities of color, particularly Black and Brown people, are amongst the most affected by Type 2 diabetes (T2D) due to socioeconomic status, cultural, and environmental factors. More than 38 million people in the US have diabetes, with up to 95% having Type 2 diabetes. While individuals aged 45 and older are typically the age range for those being diagnosed, more and more children and young adults are developing the chronic illness, according to the CDC.

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Dr. Kevin Peterson, vice president of Primary Care at the American Diabetes Association, said in an email that the environments where Black and Brown people historically live, such as areas of high carbohydrate diets, contribute to the prevalence of this illness.
Dr. Kevin Peterson, vice president of Primary Care at the American Diabetes Association, said in an email that the environments where Black and Brown people historically live, such as areas of high carbohydrate diets, contribute to the prevalence of this illness.

By Magaly Muñoz

Communities of color, particularly Black and Brown people, are amongst the most affected by Type 2 diabetes (T2D) due to socioeconomic status, cultural, and environmental factors.

More than 38 million people in the US have diabetes, with up to 95% having Type 2 diabetes. While individuals aged 45 and older are typically the age range for those being diagnosed, more and more children and young adults are developing the chronic illness, according to the CDC.

Of the 1 in 10 people with diabetes, 16.4% of Black people and 14.7% of Hispanic people make up the highest rates among different groups.

Dr. Kevin Peterson, vice president of Primary Care at the American Diabetes Association, said in an email that the environments where Black and Brown people historically live, such as areas of high carbohydrate diets, contribute to the prevalence of this illness.

But family history can also have a part to play in someone’s diagnosis. Although it is not always a determining factor, first-degree relatives, like parents, with Type 2 diabetes can increase someone’s risk of developing the same condition.

Doctors recommend that if there is that direct link, taking precautions such as a healthy diet and exercise can minimize or eliminate the chances of having T2D.

But Peterson also acknowledged that there can be difficulties with maintaining a healthy lifestyle for Black and Brown communities.

“It can be difficult in low-income communities to access healthy eating choices, and opportunities for activity can often be limited,” Peterson said. “Being creative in finding an activity that is available in your situation, finding a friend to assist you, and identifying healthy foods that you like and are available is a struggle worth taking on.”

Food deserts are one systemic factor in how people, especially low-income communities, develop chronic illnesses that can cause irreversible damage. These deserts are areas that lack easy accessibility to fresh and healthy food options.

Dr. Lloyd Stockey, MD, Internal Medicine at Kaiser Oakland Medical Center, said low-income people of color would be less susceptible to chronic illnesses like type 2 diabetes if they had more access to nutritious food.

“When you go into lower income areas or areas where people of color live, you typically see a lot of things that affect diabetes – tobacco, alcohol and fast food,” he said. “When you go out to other more affluent areas, you see more farmers’ markets, more boutique places to eat, and healthier choices. You don’t see all of that fast food.”

One of the most important things to do when talking to patients about their diagnosis, Stockey said, is meeting them where they are at. People come from all different walks of life whether that socioeconomic status, education levels, or willingness to listen to the problems they have that are contributing to their T2D.

He’s encountered patients who know exactly what the illness is, how they want to make lifestyle changes and who want to keep up with their medicine, but then there are many who are the complete opposite. These patients can be harder to get through to but no resource is left unturned for them.

Dr. Walter Acuña, MD, Internal Medicine at Kaiser Oakland Medical Center, said it’s also important to understand people’s cultures and upbringings. He understands that Latino and Black patients might be used to certain kinds of diets that are carb heavy, but added that making little changes can prevent people from having to give up the food they love.

Acuña also explained that lower income people often have time restraints or live in neighborhoods where they don’t feel safe taking a 30-minute walk. Exercising in the living room or watching online workout tutorials are excellent alternatives and can help to improve overall health.

T2D is a lifelong chronic illness but it doesn’t have to dictate someone’s life, doctors say. As long as you’re taking your prescribed medicine, watching what you eat and actively trying to make lifestyle changes, the long term risks, like liver or kidney problems, eyesight issues or early death, can be reduced.

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Bay Area

Congresswoman Lee Celebrates Federal Green Transportation Investments for California

OAKLAND, CA — Congresswoman Barbara Lee (CA-12) today celebrated the Department of Transportation’s (DOT) announcement of two grants for California to expand clean transportation infrastructure. The DOT announced that Bay Area Rapid Transit (BART) will receive over $14 million to install Level 2 EV charging ports at all BART-managed parking facilities for use by customers and community members.

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Congresswoman Barbara Lee
Congresswoman Barbara Lee

OAKLAND, CA — Congresswoman Barbara Lee (CA-12) today celebrated the Department of Transportation’s (DOT) announcement of two grants for California to expand clean transportation infrastructure. The DOT announced that Bay Area Rapid Transit (BART) will receive over $14 million to install Level 2 EV charging ports at all BART-managed parking facilities for use by customers and community members. The DOT also announced that the California Department of Transportation will receive $102 million for the West Coast Truck Charging and Fueling Corridor Project to deploy charging and hydrogen fueling stations for zero-emission medium- and heavy-duty vehicles along 2,500 miles of key freight corridors in California, Oregon, and Washington.

The transportation sector is the largest source of U.S. carbon emissions. According to the United Nations’ Intergovernmental Panel on Climate Change (IPCC), a 50 percent reduction in carbon must be achieved by 2050—and as much as a 91 percent decrease by 2100—to stay within the globally accepted goal of limiting the planet’s warming to 1.5 degrees Celsius.

“Today, I am excited to announce that BART has been selected to receive this critical federal funding to help expand mobility and end fossil fuel dependence,” said Congresswoman Lee. “It is especially important the first phase of the project will prioritize deployment at stations in or near disadvantaged communities. BART is an essential part of our public transit system, and these funds will improve transit for its riders in throughout the Bay Area.”

By installing chargers at BART stations that are close to multifamily housing, workplaces, medical facilities, schools, and retail, the project will support robust EV adoption across a wide range of socioeconomic groups and road users.

Furthermore, because of discriminatory policies, highways were built near and through Black and brown communities, making these communities much more vulnerable to chronic illnesses associated with disproportionate exposure to air pollution. A reduction in gas-powered cars will be especially beneficial to communities of color and low-income communities who have been disproportionately harmed by infrastructural and environmental injustices.

The West Coast Truck Charging and Fueling Corridor Project will enable the emissions-free movement of goods connecting major ports, freight centers, and agricultural regions between the U.S. borders with Mexico and Canada.

On this funding, Congresswoman Lee said: “This funding will go a long way toward not only combatting the climate crisis, but it will create good-paying jobs as well. I thank the Department of Transportation and the Biden-Harris administration for their continued commitment to a cleaner and healthier environment.”

Last year, alongside the California delegation, Congresswoman Lee sent a letter to DOT Secretary Pete Buttigieg urging support for the grant application of the West Coast Truck Charging and Fueling Corridor Project through the Bipartisan Infrastructure Law’s Charging and Fueling Infrastructure program.

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