Health

Study Peeks Into Healthy Brains to Hunt Alzheimer’s Culprit

Published

11 years ago

May 26, 2015

In this photo taken May 19, 2015, Judith Chase Gilbert, of Arlington, Va., is loaded into a PET scanner by Nuclear Medicine Technologist J.R. Aguilar at Georgetown University Hospital in Washington. Gilbert shows no signs of memory problems but volunteered for a new kind of scan as part of a study peeking into healthy brains to check for clues about Alzheimer’s disease. (AP Photo/Evan Vucci)

LAURAN NEERGAARD, AP Medical Writer

WASHINGTON (AP) — Sticky plaque gets the most attention, but now healthy seniors at risk of Alzheimer’s are letting scientists peek into their brains to see if another culprit is lurking.

No one knows what actually causes Alzheimer’s, but the suspects are its two hallmarks — the gunky amyloid in those brain plaques or tangles of a protein named tau that clog dying brain cells. New imaging can spot those tangles in living brains, providing a chance to finally better understand what triggers dementia.

Now researchers are adding tau brain scans to an ambitious study that’s testing if an experimental drug might help healthy but at-risk people stave off Alzheimer’s. Whether that medication works or not, it’s the first drug study where scientists can track how both of Alzheimer’s signature markers begin building up in older adults before memory ever slips.

“The combination of amyloid and tau is really the toxic duo,” predicted Dr. Reisa Sperling of Boston’s Brigham and Women’s Hospital and Harvard Medical School, who is leading the so-called A4 study. “To see it in life is really striking.”

The A4 study — it stands for Anti-Amyloid Treatment in Asymptomatic Alzheimer’s — aims to enroll 1,000 healthy seniors like Judith Chase Gilbert, 77, of Arlington, Virginia. The recently retired government worker is mentally sharp but learned through the study that her brain harbors amyloid buildup that might increase her risk. Last week, researchers slid Gilbert into a doughnut-shaped PET scanner as she became one of the first study participants to also have their brains scanned for tau.

“We know that tau starts entering the picture at some point, and we do not know when. We do not know how that interaction happens. We should know,” said chief science officer Maria Carrillo of the Alzheimer’s Association, which is pushing to add tau scans to other dementia research, too.

More than 35 million people worldwide have Alzheimer’s or similar dementias, including about 5 million in the U.S. Those numbers are expected to rise rapidly as the baby boomers get older. There is no good treatment. Today’s medications only temporarily ease symptoms and attempts at new drugs, mostly targeted at sticky amyloid, have failed in recent years.

Maybe that’s because treatment didn’t start early enough. Scientists now think Alzheimer’s begins quietly ravaging the brain more than a decade before symptoms appear, much like heart disease is triggered by gradual cholesterol buildup. Brain scans show many healthy older adults quietly harbor those sticky amyloid plaques, not a guarantee that they’ll eventually get Alzheimer’s but an increased risk.

Yet more recent research, including a large autopsy study from the Mayo Clinic, suggests that Alzheimer’s other bad actor — that tangle-forming tau protein — also plays a big role. The newest theory: Amyloid sparks a smoldering risk, but later spread of toxic tau speeds the brain destruction.

Normal tau acts sort of like railroad tracks to help nerve cells transport food and other molecules. But in Alzheimer’s, the protein’s strands collapse into tangles and eventually the cell dies. Most healthy people have a small amount of dysfunctional tau in one part of the brain by their 70s, Sperling said. But amyloid plaques somehow encourage this bad tau to spread toward the brain’s memory center, she explained.

The A4 study, which is enrolling participants in the U.S., Australia and Canada, may give some clues.

The goal is to check up to 500 people for tau three times over the three-year study, as researchers tease out when and how it forms in those who are still healthy. They won’t be told the results — scientists don’t know enough yet about what the scans portend.

At the same time, study participants will receive either an experimental anti-amyloid drug — Eli Lilly & Co.’s solanezumab — or a placebo as researchers track their memory. The $140 million study is funded by the National Institutes of Health, Lilly and others; the Alzheimer’s Association helped fund the addition of the tau scans.

The idea: If the drug proves to be helpful, it might be tamping down amyloid formation that in turn reins in toxic tau. In previous studies, solanezumab failed to help full-blown Alzheimer’s but appeared to slow mental decline in patients with mild disease, raising interest in testing the still healthy.

“We’re trying to remove amyloid’s downstream effects on tau formation,” said Dr. R. Scott Turner of Georgetown University Medical Center, where Gilbert enrolled in the study.

Seeing how amyloid and tau interact in living brains “is opening a whole new chapter into possible therapies,” Turner added.

For Gilbert, learning she had amyloid buildup “was distressing,” but it has prompted her to take extra steps, in addition to the study, to protect her brain. On her doctor’s advice, she’s exercising more, and exercising her brain in a new way by buying a keyboard to start piano lessons.

“It’s exciting to be part of something that’s cutting edge,” said Gilbert, who had never heard of tau before.

And she has a spot-on question: “So what’s the medication for the tau?”

Stay tuned: A handful of drugs to target tau also are in development but testing will take several years.

___

Online: www.a4study.org

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COMMENTARY: The Biases We Don’t See — Preventing AI-Driven Inequality in Health Care

For decades, medicine promoted false assumptions about Black bodies. Black patients were told they had lower lung capacity, and medical devices adjusted their results accordingly. That practice was not broadly reversed until 2021. Up until 2022, a common medical formula used to measure how well a person’s kidneys were working automatically gave Black patients a higher score simply because they were Black. On paper, this made their kidneys appear healthier than they truly were. As a result, kidney disease was sometimes detected later in Black patients, delaying critical treatment and referrals.

Published

2 months ago

February 10, 2026

Oakland Post

Sen. Akilah Weber Pierson, M.D (D-San Diego). File photo.

By Sen. Akilah Weber Pierson, M.D., Special to California Black Media Partners

Technology is sold to us as neutral, objective, and free of human flaws. We are told that computers remove emotion, bias, and error from decision-making. But for many Black families, lived experience tells a different story. When technology is trained on biased systems, it reflects those same biases and silently carries them forward.

We have seen this happen across multiple industries. Facial recognition software has misidentified Black faces at far higher rates than White faces, leading to wrongful police encounters and arrests. Automated hiring systems have filtered out applicants with traditionally Black names because past hiring data reflected discriminatory patterns. Financial algorithms have denied loans or offered worse terms to Black borrowers based on zip codes and historical inequities, rather than individual creditworthiness. These systems did not become biased on their own. They were trained on biased data.

Healthcare is not immune.

These biases were not limited to software or medical devices. Dangerous myths persisted that Black people feel less pain, contributing to undertreatment and delayed care. These beliefs were embedded in modern training and practice, not distant history. Those assumptions shaped the data that now feeds medical technology. When biased clinical practices form the basis of algorithms, the risk is not hypothetical. The bias can be learned, automated, and scaled.

For us in the Black community, this creates understandable fear and mistrust. Many families already carry generational memories of medical discrimination, from higher maternal mortality to lower life expectancy to being dismissed or unheard in clinical settings. Adding AI biases could make our community even more apprehensive about the healthcare system.

As a physician, I know how much trust patients place in the healthcare system during their most vulnerable moments. As a Black woman, I understand how bias can shape experiences in ways that are often invisible to those who do not live them. As a mother of two Black children, I think constantly about the systems that will shape their health and well-being. As a legislator, I believe it is our responsibility to confront emerging risks before they become widespread harm.

That is why I am the author of Senate Bill (SB) 503. This bill aims to regulate the use of artificial intelligence in healthcare by requiring developers and users of AI systems to identify, mitigate, and monitor biased impacts in their outputs to reduce racial and other disparities in clinical decision-making and patient care.

Currently under consideration in the State Assembly, SB 503 was not written to slow innovation. In fact, I encourage it. But it is our duty must ensure that every tool we in the healthcare field helps patients rather than harms them.

The health of our families depends on it.

About the Author

Sen. Akilah Weber Pierson (D–San Diego) is a physician and public health advocate representing California’s 39th Senate District.

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As California Hits Aging Milestone, State Releases Its Fifth Master Plan for Aging

“California’s Master Plan for Aging started a powerful movement that is shaping the future of aging in our state for generations to come,” Gov. Gavin Newsom said in a statement, calling the initiative a “future-forward” model delivering real results for older adults, people with disabilities, and their families.

Published

2 months ago

February 9, 2026

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By Bo Tefu, California Black Media

On Jan. 27, California released its Fifth Master Plan for Aging Annual Report,titled “Focusing on What Matters Most,” outlining the state’s progress and priorities as its population rapidly grows older.

The report, issued by the California Health and Human Services Agency (CalHHS), provides updates on the Master Plan for Aging’s “Five Bold Goals”: housing, health, inclusion and equity, caregiving, and affordability.

The report comes as Californians aged 60 and older now outnumber those under 18 for the first time, a demographic shift expected to accelerate over the next decade.

Launched in 2021, the Master Plan for Aging takes a “whole-of- government” and “whole-of-society” approach, coordinating state agencies, local governments, community organizations, and private partners. The annual report highlights significant milestones, including more than 100 California communities joining AARP’s Age-Friendly Network and $4 million in state funding awarded to local organizations to develop aging and disability action plans in 30 communities statewide.

The report also underscores California’s leadership at the national level, noting that dozens of states have followed its example and that federal legislation inspired by the plan was reintroduced in the U.S. Senate in December 2025.

CalHHS Secretary Kim Johnson emphasized the plan’s focus on equity and resilience amid ongoing challenges.

“The Master Plan for Aging continues to provide a vision, a focus, and a platform for collaboration,” Johnson said. “Equity is at the center of all that we do.”

Looking ahead, the report notes that by 2030, one in four Californians will be age 60 or older, positioning the Master Plan for Aging as a central framework for meeting the state’s long-term social, economic, and health needs.

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Candidates Vying for Governor’s Seat Debate at Ruth Williams–Bayview Opera House in San Francisco

The gubernatorial debate participants included Antonio Villaraigosa, former Los Angeles mayor; Matt Mahan, San Jose mayor; Betty Yee, former California state controller; Xavier Becerra, former U.S. Secretary of Health and Human Services, and attorney general of California; Steve Hilton, political commentator and political adviser; Tom Steyer, entrepreneur, and Tony Thurmond, California’s superintendent of public instruction.

Published

2 months ago

February 9, 2026

Oakland Post

The gubernatorial debate was hosted by KTVU’s Greg Lee, KTTV’s Marla Tellez and KTVU’s Andre Senior. The candidates are (l.-r.): Xavier Becerra, Steve Hilton, Matt Mahan, Tom Steyer, Tony Thurmond, Antonio Villaraigosa, and Betty Yee.

By Carla Thomas

On Tuesday, Feb. 3, seven candidates took the stage at the historic Ruth Williams–Bayview Opera House in San Francisco for the gubernatorial debate, hosted by the Black Action Alliance (BAA) in partnership with KTVU and sister station KTTV Fox 11 in Los Angeles.

For many voters, it marked a first opportunity to hear directly from several candidates seeking to lead the nation’s most populous state.

Crucial topics and issues addressed throughout the debate included housing, crime, immigration, climate change, health care and homelessness.

The debate was moderated by KTVU political reporter Greg Lee alongside KTVU’s Andre Senior and KTTV Fox 11’s Marla Tellez.

Candidates also addressed inflation and the rising costs across the state, impacting everything from groceries to childcare and health care.

Thurmond vowed to generate 2.3 million units of housing by placing 12 units on each parcel of available land in the 58 counties of California. Steyer agreed that billionaires should pay their fair share of taxes.

Hilton wanted to cut taxes, help working-class families, and end the Democrats “climate crusade and insane regulations.”

Yee offered a more transparent governmental approach with accountability, given the state’s debt.

Gonzalez said, “This debate was a great way to see who has great ideas and who has substance.”

“It’s important to have the debate within a community that requires the most,” said business leader Linda Fadekye.

Attendees included State Controller Malia Cohen, representatives of the National Coalition of 100 Black Women, the National Coalition of 100 Black Men, the San Francisco African American Chamber of Commerce, and Black Women Organized for Political Action, among others.

Event host, the Black Action Alliance (BAA) was established to amplify the voices of the Bay Area’s Black community, whose perspectives have too often been overlooked in politics and public policy.

Loren Taylor, CEO of BAA, said it was important to bring the event to the Bayview in San Francisco and shared his organization’s mission.

“The Black Action Alliance (BAA) stands for practical, community-driven solutions that strengthen public safety, address homelessness, support small businesses, expand affordable housing, and ensure access to quality education—issues at the heart of the Black experience in the Bay Area,” said Taylor.

California’s primary election will take place on June 2 and the general election will take place on Nov. 3.