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Study: Silent Cancer in Moms a Rare Result in Prenatal Tests

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LINDSEY TANNER, AP Medical Writer

CHICAGO (AP) — For pregnant women, abnormal results from certain prenatal tests may signal that something is wrong — with the moms-to-be, not the fetus, a preliminary study suggests.

Very rarely, these results may indicate cancer in the women when follow-up testing shows the fetus is healthy.

The noninvasive tests are increasingly being used to detect fetal chromosome abnormalities, including Down syndrome. They test pregnant women’s blood, which contain small amounts of fetal DNA. But cancer is among conditions that can cause results that mistakenly indicate an abnormality in the fetus, the researchers say. The results are not definitive, although smaller studies have had similar findings.

Some highlights from the research, published online Monday in the Journal of the American Medical Association.

THE DETAILS

The study involved blood tests from more than 100,000 women, processed over nearly three years by a Redwood City, California, laboratory. Nearly 4,000 women, or about 3 percent, had results suggesting fetal chromosome abnormalities. In 10 cases, the babies turned out to be healthy but the women were later diagnosed with cancer, including lymphoma, leukemia and colon cancer.

The study focused on eight of these women, who were diagnosed within weeks to several months of the test.

Most had prenatal tests suggesting more than one chromosome abnormality in the baby. In three women, cancer was diagnosed during a medical work-up prompted by the prenatal test results. Other cancers were discovered after women developed symptoms. Two women had advanced cases.

THE TESTS

Noninvasive prenatal tests for fetal chromosome abnormalities are increasingly being recommended for women at high risk of having a child with Down syndrome; about 2 million tests have been performed worldwide, said lead author Dr. Diana Bianchi. False-positive results are rare; they occur in just 0.2 percent of tests at the lab involved in the study, said Bianchi, executive director of Tufts Medical Center’s Mother Infant Research Institute.

False-positives can occur for several reasons, including a twin pregnancy when one twin dies, and when the mother has a transplanted organ from a male donor. Cancer cells shed DNA that the tests can detect. It’s a rare cause of false-positives but Bianchi said more definitive data are needed to determine the incidence.

THE ADVICE

“We don’t know how many people are walking around with silent cancers this test is accidentally uncovering,” Bianchi said. Women should be aware of the possibility when they seek the prenatal tests, and when results suggest a fetal problem, follow-up testing including amniocentesis is recommended.

But Bianchi said it would be premature to recommend cancer testing for all women whose tests have false-positive results.

A JAMA editorial says more rigorous research is needed to help doctors determine how to counsel these women.

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Online: http://www.jama.com

Prenatal testing: http://bit.ly/1Cv8ZQ0

___

AP Medical Writer Lindsey Tanner can be reached at http://www.twitter.com/LindseyTanner

Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Black History

Doulas Are Helping Black California Moms Navigate Pregnancy–Even as High Mortality Rates Persist

In California, Black women experience the highest pregnancy-related mortality rate — about four times greater than other women, according to statistics. From 2021 to 2023, the leading causes of pregnancy-related deaths included cardiovascular disease, COVID-19, hemorrhage, sepsis, amniotic fluid embolism, and pulmonary embolism.

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Long Beach resident Cassandra Carter approached the birth of her daughter, Nyomi (pictured), last November with anxiety after losing twins. She is pictured here with her husband.

After losing twins, Long Beach resident Cassandra Carter approached the birth of her daughter, Nyomi, last November with anxiety. She wanted support for herself and her husband, Adewole, that extended beyond routine medical care. 

“Getting pregnant as a Black woman, I wanted a team around me that made me feel safe,” she said. “I know all about the mishaps that Black women experience.”  

Carter, a therapist and self-described hippie, hired Yvette Perry, a doula and co-founder of Divine Birthing Services LLC in Lancaster. Perry helped Cassandra craft a detailed birth plan. 

“I was worried about postpartum depression. Mrs. Yvette knows a lot about how postpartum affects men as well,” Carter explained. 

Perry was present the day Nyomi was born. She held the baby when Carter or her husband needed a moment and even set up candles in the birthing suite.  

“Whatever I needed for my comfort, she was there,” Carter said of Perry. “She was there as an advocate and voice. I had a really serene birthing experience because I had someone extra who wasn’t tied to me as my family.”  

Perry, a doula for nearly six years, said preexisting conditions, poor communication and dismissive hospital care heighten health risks for Black mothers. 

“Sometimes, Black mommies are not being heard. They don’t know they have rights. They don’t know they can say, ‘no,’” Perry explained. “Doulas empower them. We are there to educate them.” 

Perry’s concerns reflect a broader public health crisis. According to the Centers for Disease Control and Prevention’s 2024 maternal mortality report, non-Hispanic Black women in the U.S. died from pregnancy-related causes at a rate of 44.8 deaths per 100,000 live births. 

In California, Black women experience the highest pregnancy-related mortality rate — about four times greater than other women, according to statistics. From 2021 to 2023, the leading causes of pregnancy-related deaths included cardiovascular disease, COVID-19, hemorrhage, sepsis, amniotic fluid embolism, and pulmonary embolism. 

The Centering Black Mothers in California report found that structural racism — including barriers to high-quality health care, and chronic stress— disproportionately harms Black women. 

In a statement to California Black Media (CBM), the California Department of Public Health (CDPH) said maternal mortality disparities stem from multiple factors. The department said addressing structural racism, listening to Black women’s experiences and reducing provider bias are key to closing the gap. 

California began covering doula care as a Medi-Cal benefit in 2023, providing eligible patients with support during pregnancy, childbirth and the postpartum period, according to CDPH.  

Whitney Dotson of Inglewood wanted an expert on pregnancy, labor, and delivery to guide her and her husband, Anthony, through the birth of their son, Anthony III. So, she hired Perry for doula support. 

“It’s always more comfortable when you can have a second opinion,” she said. “Knowing she was better versed in what the options were, made me more comfortable.” 

Dotson, 39, had a healthy pregnancy but faced recommendations common for expectant mothers over 35. Her doctor advised inducing labor at 39 weeks, but she hoped to carry to full term. 

“I wasn’t comfortable with that,” she admitted. 

Perry provided Dotson with information about induction guidelines and alternatives, helping her understand her options and communicate her preferences.  

Then, Dotson returned to her doctor. 

“I said, ‘I don’t want to — and this is why,’” she recalled. “He agreed and pushed the induction date back a week.” 

Perry also advised Anthony on how he could support his wife during and after the pregnancy and during Anthony III’s birth. She also reminded Dotson to change birthing positions — from her back to her hands and knees.  

Before Saveneh Martinez became a doula with Fierce Advocates in Contra Costa County, she was a new mom, uneducated on aspects of birth, which led to her first child, Colton, being placed in a Neonatal Intensive Care Unit. 

“I didn’t know my choices,” she said.   

Martinez called it “lifesaving” for expecting moms to have a doula.  

“It should be a medical right,” she said.  

California Perinatal Quality Care Collaborative (CPQCC) Senior Associate Medical Director Kimberly D. Gregory said research suggests that doulas decrease the pre-term birth rate and the likelihood of a C-section.  

“Having a doula is a proactive thing to do,” she said.  

Efforts are being made across the state to reduce maternal deaths.  

CDPH’s Title V Action Plan aims to reduce pregnancy-related deaths among Black birthing mothers from 49.7 to 42.3 per 100,000 live births by 2030 through improvements in patient-centered care, expanding community-based perinatal teams, and addressing the social factors that contribute to poor maternal health outcomes. 

CDPH’s Black Infant Health (BIH) Program and Perinatal Equity Initiative (PEI) have already begun to make headway.  

“BIH’s prenatal group model improves key intermediate outcomes for participants, including increased social support and empowerment, better stress management, reduced depressive symptoms and gains in health knowledge and behaviors such as safe sleep practices and reduced smoking,” the CDPH told CBM.  

“PEI’s early implementation results show progress across several participant-reported areas, such as improved birth experiences, breastfeeding initiation, and coparenting skills among fathers and partners,” the CDPH statement continued.  

Gregory said the California Pregnancy Associated Review Committee examines maternal deaths and develops guidelines to help hospitals improve care. One of its main recommendations focuses on how hospitals respond to hemorrhaging, a leading cause of pregnancy-related deaths. 

Gregory said CMQCC also created standard clinic care practices for cardiovascular disease and sepsis, two more drivers of maternal mortality, but widespread implementation across the state is pending.  

She noted that although there are 800 maternal deaths a year in the U.S., there are also 3.6 million births.  

“Most people will do well,” she said. “But you should know about complications like preterm birth. You should know about complications like diabetes, preeclampsia and postpartum depression.” 

Martinez said doulas help to make birthing the transformative experience that it is, instead of a routine clinical transaction. 

“Being able to feel heard, seen, safe, respected, and just being able to create spaces for them to be held as well,” she said.  

Supported by the California Health Care Foundation (CHCF), which works to ensure that people have access to the care they need, when they need it, at a price they can afford. Visit www.chcf.org to learn more.

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Featured

On Your November Ballot: Prop 38 Would Allocate $8.4 Billion to Immunology and Immunotherapy Funding

“Yes on 38”, with the tagline “Californians for Life-Saving Immunology Research and Cures,” is leading the campaign for the support side of the proposition.

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California voters will decide in November whether Proposition (Prop) 38 should authorize substantial state funding for immunology and immunotherapy research.

The initiative would fund immunology and immunotherapy research aimed at harnessing the body’s immune system to develop new treatments, medical procedures and potential cures for diseases such as cancer, Alzheimer’s disease and heart disease.

More specifically, Prop 38, titled the Immunology and Immunotherapy Research Funding Initiative, is split into three main components that would go into effect if passed.

First, the initiative would authorize the state to issue $8.4 billion in general obligation bonds to support immunology and immunotherapy research. At least half of the bond proceeds, or $4.2 billion, would be dedicated exclusively to research.

Additionally, Prop 38 would make it mandatory for the state to enter into an agreement with a qualified nonprofit institute focused and dedicated to researching immunology and immunotherapy within 90 days of the initiative’s effective date. The research institute must be affiliated with the University of California. 

The third component mandates that the remaining bond revenue must be directed to California-based public and nonprofit medical institutions through a peer-reviewed grant process.  

“Yes on 38”, with the tagline “Californians for Life-Saving Immunology Research and Cures,” is leading the campaign for the support side of the proposition. 

Along with the campaign, organizations that have publicly supported the ballot initiative include the California Democratic Party, The ALS Association, Alzheimer’s treatment and advocacy organizations, California Black Health Network, Parkinson Association of Northern California and Reform California among others.

“California has an opportunity to accelerate lifesaving medical breakthroughs. Immunotherapies work differently than traditional treatments. Instead of attacking cells directly, they empower the body’s own immune system to recognize and stop disease. Today, these therapies are already treating certain cancers and chronic conditions — and researchers continue to expand what’s possible. This initiative invests in proven science so cures can move from the lab to patients faster,” said the campaign.

No on Proposition 38 is leading the campaign against the measure, with support from the League of Women Voters of California. Opponents argue that California cannot afford to assume $8.4 billion in debt for medical research that may not produce definitive results. They also object to directing more than half of the bond proceeds — $4.2 billion — to a single qualifying nonprofit research institute, arguing that funding decisions of this magnitude should be made through the state’s regular budget process.

“Medical research can save lives, but Prop 38 is the wrong way to fund it. It would authorize $8.4 billion in borrowing for immunology and immunotherapy research and require the state to make $500 million to $600 million in annual debt payments for about 20 years. Those payments would come from the General Fund, which also pays for schools, health care, and other public services,” the League of Women Voters of California said.

A “yes” vote would authorize $8.4 billion in state bonds to fund immunology and immunotherapy medical research.

A “no” vote would reject the proposed bond funding.

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Community

Two Looming Threats Every Alameda County Elder Should Know About

Federal changes enacted under H.R. 1 are bringing new eligibility, reporting, and coverage rules beginning in 2027. Although Californians age 65 and older and people with disabilities are exempt from the new 80-hour-per-month work requirement and will continue with annual rather than six-month renewals, that does not mean elders can ignore the coming changes.

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Alameda County elders are urged to attend the Elder Justice Symposium at Oakland City Hall on Sept. 25, from 9 a.m. to 5 p.m., for information that could profoundly affect both their health care and the legacy they hope to leave their families.

For many older adults, a lifetime of hard work has produced two things they understandably want to protect: access to health care while they are living and the home, savings, and other assets they hope to pass to loved ones when they die.

Changes already underway in California make understanding how to protect both increasingly urgent.

The first threat involves Medi-Cal.

Federal changes enacted under H.R. 1 are bringing new eligibility, reporting, and coverage rules beginning in 2027. Although Californians age 65 and older and people with disabilities are exempt from the new 80-hour-per-month work requirement and will continue with annual rather than six-month renewals, that does not mean elders can ignore the coming changes.

California has already reinstated an asset test for certain Medi-Cal recipients age 65 and older, people with disabilities and those needing long-term care. Assets must be reported when applying or renewing coverage.

And another significant change is coming.

Beginning July 1, 2027, California says the Medi-Cal asset limit for affected beneficiaries will fall from $130,000 for one person to just $21,000, and to $31,000 for two people, with certain assets excluded and special rules applying in some circumstances.

There is more. Beginning Jan. 1, 2027, Medi-Cal’s retroactive coverage period will also shrink. For most beneficiaries outside the ACA expansion adult group, coverage of qualifying medical expenses incurred before application will be reduced from three months to two.

For an elder facing hospitalization, long-term care or an unexpected medical crisis, misunderstanding these rules could have enormous financial consequences.

The second threat concerns what happens to everything you worked so hard to acquire.

Many people believe, “I have a will and a living trust, so my family is protected.”

It may not be that simple.

An estate plan is only as effective as the way it has been structured, maintained and implemented. How assets are titled, whether a trust has actually been funded, beneficiary designations, Medi-Cal eligibility and long-term-care planning can all affect whether a person’s wishes are ultimately carried out.

A will by itself does not automatically avoid probate, and simply possessing trust documents does not mean every asset has been properly protected or positioned to pass as intended.

That is why elders should learn the rules before a medical crisis, incapacity or death makes planning far more difficult.

At the Elder Justice Symposium, experts will explain these changes in understandable language and discuss steps that elders and their families should consider now.

Attendees will have an opportunity to learn what questions to ask about Medi-Cal eligibility and renewals, asset limits, estate planning and protecting the legacy they intend for their families.

Do not assume the rules you learned years ago are still the rules governing you today.

Come to Oakland City Hall on Sept. 25, from 9 a.m. to 5 p.m.

Bring your questions. Bring your family. Most importantly, bring a willingness to prepare.

The decisions you make before these changes take full effect could profoundly affect your health care, your financial security, and what remains for the people you love.

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