Berkeley

Discovery Paves Way for Homebrewed Drugs, Prompts Call for Regulation

Published

11 years ago

May 26, 2015

By Sarah Yang, UC Berkeley News

Fans of homebrewed beer and backyard distilleries already know how to employ yeast to convert sugar into alcohol.

But a research team led by UC Berkeley bioengineers has gone much further by completing key steps needed to turn sugar-fed yeast into a microbial factory for producing morphine and potentially other drugs, including antibiotics and anti-cancer therapeutics.

Over the past decade, a handful of synthetic-biology labs have been working on replicating in microbes a complex, 15-step chemical pathway in the poppy plant to enable production of therapeutic drugs.

Research teams have independently recreated different sections of the poppy’s drug pathway using E. coli or yeast, but what had been missing until now were the final steps that would allow a single organism to perform the task from start to finish.

In a new study appearing this week in the advanced online publication of the journal Nature Chemical Biology, UC Berkeley bioengineer John Dueber teamed up with microbiologist Vincent Martin at Concordia University in Montreal, to overcome that hurdle by replicating the early steps in the pathway in an engineered strain of yeast.

They were able to synthesize reticuline, a compound in poppy, from tyrosine, a derivative of glucose.

“What you really want to do from a fermentation perspective is to be able to feed the yeast glucose, which is a cheap sugar source, and have the yeast do all the chemical steps required downstream to make your target therapeutic drug,” said Dueber, the study’s principal investigator and an assistant professor of bioengineering. “With our study, all the steps have been described, and it’s now a matter of linking them together and scaling up the process. It’s not a trivial challenge, but it’s doable.”

The qualities that make the poppy plant pathway so challenging are the same ones that make it such an attractive target for research. It is complex, but it is the foundation upon which researchers can build new therapeutics. Benzylisoquinoline alkaloids, or BIAs, are the class of highly bioactive compounds found in the poppy, and that family includes some 2,500 molecules isolated from plants.

Perhaps the best-known trail in the BIA pathway is the one that leads to the opiates, such as codeine, morphine and thebaine, a precursor to oxycodone and hydrocodone.

All are controlled substances. But different trails will lead to the antispasmodic papaverine or to the antibiotic precursor dihydrosanguinarine.

“Plants have slow growth cycles, so it’s hard to fully explore all the possible chemicals that can be made from the BIA pathway by genetically engineering the poppy,” said study lead author William DeLoache, a UC Berkeley Ph.D. student in bioengineering.

“Moving the BIA pathway to microbes dramatically reduces the cost of drug discovery. We can easily manipulate and tune the DNA of the yeast and quickly test the results,” he said.

The researchers found that by repurposing an enzyme from beets that is naturally used in the production of their vibrant pigments, they could coax yeast to convert tyrosine, an amino acid readily derived from glucose, into dopamine.

With help from the lab of Concordia University’s Vincent Martin, the researchers were able to reconstitute the full seven-enzyme pathway from tyrosine to reticuline in yeast.

“Getting to reticuline is critical because from there, the molecular steps that produce codeine and morphine from reticuline have already been described in yeast,” said Martin, a professor of microbial genomics and engineering. “Also, reticuline is a molecular hub in the BIA pathway. From there, we can explore many different paths to other potential drugs, not just opiates.”

The study authors noted that the discovery dramatically speeds up the clock for when homebrewing drugs could become a reality, and they are calling for regulators and law enforcement officials to pay attention.

“We’re likely looking at a timeline of a couple of years, not a decade or more, when sugar-fed yeast could reliably produce a controlled substance,” said Dueber. “The time is now to think about policies to address this area of research. The field is moving surprisingly fast, and we need to be out in front so that we can mitigate the potential for abuse.”

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Activism

Black Repertory Group Needs Volunteers to Help Shape the Next Generation of Artists and Leaders

Legendary performers such as Whoopi Goldberg and Danny Glover worked with and were inspired by BRG’s founders. More recently, Grammy award-winning artist Kehlani attended the Black Repertory Group Summer Day Camp for several years.

Published

3 months ago

June 26, 2026

Oakland Post

Courtesy image.

By Sean Vaughn Scott, Special to The Post

For more than 60 years, the Black Repertory Group (BRG) has changed lives through the arts.

Founded in 1964 by educators and visionaries Birel L. Vaughn and Nora Vaughn, BRG has become one of America’s oldest continuously operating Black theater institutions. For generations, it has preserved culture, developed talent, and provided opportunities for young people to discover their voices and their potential.

The results speak for themselves.

Long before international recognition, Kehlani performed on the BRG stage. During a summer day camp production of “Princess and da Frog,” she portrayed Ray, the lovable firefly whose light guided others through the darkness. Her journey is proof that today’s camper may become tomorrow’s artist, entrepreneur, educator, or leader.

Located at 3201 Adeline St. in Berkeley, BRG continues that mission through its Youth Summer Day Camp of the Arts.

BRG is currently accepting applications and maintains an open enrollment program. Students may enroll throughout the summer as space permits and immediately become part of the BRG family.

We are also proud to be a multicultural opportunity program, welcoming children and families from all backgrounds, cultures, and communities. Through theater, music, dance, public speaking, visual arts, technical theater, and leadership development, students gain confidence, discipline, creativity, and lifelong skills.

As our programs grow, so does our need for volunteers.

We are seeking community members to assist with youth mentoring, registration, costumes, set construction, painting, props, ushering, photography, social media, marketing, technical theater, and fundraising activities. Whether you volunteer for a few hours or throughout the season, your support directly impacts the lives of young people.

BRG also partners with churches, civic organizations, alumni associations, fraternities, sororities, and community groups through theater party fundraisers, group sales, and buy-out performances. These partnerships have helped organizations raise funds while supporting arts and cultural programming.

The theater also serves as the home of the Berkeley NAACP Chapter, which meets every second Saturday of the month from 1 to 3 p.m.

For more than six decades, the Black Repertory Group has remained committed to one belief: every child deserves an opportunity to shine.

The next great artist may already be among us.

The next Kehlani may already be walking through our doors.

We invite you to volunteer, enroll, participate, and become part of the legacy.

For more information please go to www.blackrepertorygroup.com, call (510) 652-2120, or email info@blackrepertorygroup.com

Sean Vaughn Scott is the director of the Black Repertory Group.

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Bay Area

UC Berkeley Named Top Public University in the U.S. and No. 7 in the World by ‘U.S. News’

Berkeley has been consistently awarded the distinction of the U.S.’s top public university since the Best Global Universities list was first published in 2014. “A strong position in the Best Global Universities rankings recognizes a school’s profound commitment to world-class research and cross-border academic excellence,” said LaMont Jones, managing editor for education at U.S. News.

Published

3 months ago

June 24, 2026

Oakland Post

Photo by Keegan Houser/UC Berkeley.

The 2026 Best Global Universities rankings evaluated 2,250 research institutions from more than 100 countries

By Lila Thulin

U.S. News & World Report has ranked UC Berkeley No. 7 in its 2026 list of the best global universities, which assesses more than 2,250 research institutions worldwide.

Berkeley also claimed the honor of top public university in the U.S.

Released on Monday, the list evaluates universities from more than 100 countries on 13 metrics such as global and research reputation (as reported by academics and peers) and number of highly cited scholarly papers.

Berkeley has been consistently awarded the distinction of the U.S.’s top public university since the Best Global Universities list was first published in 2014.

“A strong position in the Best Global Universities rankings recognizes a school’s profound commitment to world-class research and cross-border academic excellence,” said LaMont Jones, managing editor for education at U.S. News.

The rankings also assess a university’s strength in various subject areas; these assessments are separate from U.S. News’ 2026 Best Graduate Programs rankings released in April.

This year, Berkeley was named in the top three nationally in seven subject areas – environment/ecology, ecology, water resources, physics, computer science, chemistry, and engineering – and in the top five for a total of 17 subjects. Subject rankings are based heavily on scholarly publications and citations as well as reputation.

In September, U.S. News also released its 2026 Best Colleges list, in which Berkeley was also named the No. 1 public institution among American universities.

That honor joins other accolades judging campus to be the best public university in the country, such as those from Forbes, The Wall Street Journal and Times Higher Education.

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Arts and Culture

Farwest Region Deltas Celebrate Centennial With “September Breakfast” Honoring Vivian Osborne Marsh

The region was established in 1925 under the leadership of Vivian Osborne Marsh, who became its first Regional Director. Marsh was a pioneering scholar and civic leader, earning recognition as the first Black woman to receive both a bachelor’s and a master’s degree in anthropology from UC Berkeley.

Published

1 year ago

September 14, 2025

Oakland Post

Farwest Regional Director, Kimberly Usher, Mayor Barbara Lee, US Representative Lateefah Simon, and Farwest Regional Representative, Radiya Ajibade. Photo courtesy of Farwest Regional Photographer Vicki P. Love.

By Antoinette Porter

Hundreds of members of Delta Sigma Theta Sorority, Inc., and their guests gathered at the Martin Luther King Jr. Student Union at the University of California, Berkeley, to mark the 100th anniversary of the sorority’s Farwest Region.

Marsh went on to serve as Delta Sigma Theta’s 7th National President, where she launched the sorority’s National Library Project to expand access to books in underserved Black communities in the South. During her presidency, the organization also became a prominent voice in the civil rights movement, lobbying Congress to pass anti-lynching legislation.

Bak in the Bay Area, Marsh devoted her career to advancing educational opportunities, mentoring young people, and strengthening community life. That commitment continues to shape the region, which supports initiatives in education, social justice, and economic development. Current projects include raising scholarship funds for students at Historically Black Colleges and Universities, voter education campaigns, and health and wellness programs.

A century after its founding, the Farwest Region of Delta Sigma Theta remains active across California and other western states, carrying forward Marsh’s vision of service and advocacy.