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Breakthrough Research Sheds Light on Aggressive Breast Cancers in Black Women

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center are spearheading a pioneering study to unravel the biological underpinnings of aggressive breast cancers in Black women. Led by Dr. Harikrishna Nakshatri, a breast cancer researcher at the IU School of Medicine and a key researcher at the Vera Bradley Foundation Center for Breast Cancer Research at the IU Simon Comprehensive Cancer Center, the investigation holds promise for targeted treatments that could significantly reduce disparities in breast cancer outcomes among Black women.

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While breast cancer incidence is now considered lower among Black women, they face significantly poorer outcomes, often developing more aggressive triple-negative breast cancers at a younger age. Photo image courtesy of NNPA Newswire.
While breast cancer incidence is now considered lower among Black women, they face significantly poorer outcomes, often developing more aggressive triple-negative breast cancers at a younger age. Photo image courtesy of NNPA Newswire.

By Stacy M. Brown
NNPA Newswire

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center are spearheading a pioneering study to unravel the biological underpinnings of aggressive breast cancers in Black women.

Led by Dr. Harikrishna Nakshatri, a breast cancer researcher at the IU School of Medicine and a key researcher at the Vera Bradley Foundation Center for Breast Cancer Research at the IU Simon Comprehensive Cancer Center, the investigation holds promise for targeted treatments that could significantly reduce disparities in breast cancer outcomes among Black women.

While breast cancer incidence is now considered lower among Black women, they face significantly poorer outcomes, often developing more aggressive triple-negative breast cancers at a younger age.

“Even after you correct for socioeconomic and healthcare access factors, African ancestry is still associated with the worst outcomes,” Nakshatri emphasized.

Nakshatri’s lab has been dedicated to uncovering the influence of genetic ancestry on the biology of normal breast tissue and its implications for developing aggressive breast cancers.

Women of African descent had more PZP cells in their normal breast tissue than women of Caucasian descent, according to a previous study under Nakshatri’s direction. Notably, PZP cell numbers increase when Caucasian women develop breast cancer, while they are naturally more abundant in Black women.

Adding to this, Nakshatri and his team showed that PZP cells have a significant effect on how cancer cells behave and grow, especially when they interact with epithelial cells, which is where breast cancer usually starts.

Researchers have also found that PZP cells are one of the sources of metaplastic breast cancers (MBC), which are rare and aggressive and make up less than 1% of all breast cancers.

The team drew upon tissue samples from the Susan G. Komen Tissue Bank at the IU Simon Comprehensive Cancer Center, the world’s sole repository of healthy breast tissue, to conduct this research.

“When these PZP cells interact with epithelial cells, they trigger the production of a crucial protein called interleukin-6. This prompts distinct behavior in the epithelial cells and activates a signaling pathway known as STAT3,” Nakshatri explained. “This is what makes tumors originating from the epithelial cells more aggressive.”

The findings have laid the foundation for an upcoming clinical trial led by Kathy Miller, MD, a prominent figure in oncology at IU School of Medicine.

Miller also serves as the Ballvé Lantero professor of oncology and holds the position of associate director of clinical research at the cancer center, in addition to her role as a researcher at the Vera Bradley Foundation Center.

“This study could help us determine if physicians need to consider the genetic ancestry of the person when deciding on possible treatments for breast cancer,” Nakshatri stated.

Based on the biology of normal breast tissue, he said the study represents a significant departure from conventional treatment approaches, offering new hope for more effective, targeted treatments in the fight against breast cancer.

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Arts and Culture

COMMENTARY: Black Music is the Sound of Black Freedom: Let Us Reclaim Both This Juneteenth

Black Music Month started when Black Music Association members Ed Wright, Kenny Gamble and his wife, journalist and radio host Dyanna Williams were able to persuade President Jimmy Carter to establish the observation on June 7, 1979.

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Robert Johnson (1911-1938) is thought of as the godfather of blues music, especially Delta blues. The 29 songs recorded by him during his short life have been of massive inspiration to guitarists and musicians over the last 80 years. Public domain photo.
Robert Johnson (1911-1938) is thought of as the godfather of blues music, especially Delta blues. The 29 songs recorded by him during his short life have been of massive inspiration to guitarists and musicians over the last 80 years. Public domain photo.

By Wanda Ravernell

Black Music Month and Juneteenth are inextricably linked – Black music is the sound of our freedom.

From the plaintive moans of the enslaved Africans’ ‘sorrow songs,’ to the fields of Civil War battle where Black soldiers picked up abandoned bugles, to the upright piano played in juke joints on Saturday night and churches come Sunday morning, our ancestors’ innovation in the face of want, fear, degradation, and hopelessness has yielded genres of music imitated ’round the world.

Black Music Month started when Black Music Association members Ed Wright, Kenny Gamble and his wife, journalist and radio host Dyanna Williams were able to persuade President Jimmy Carter to establish the observation on June 7, 1979.

In 2000, Congress made it official. In 2009, Pres. Barack Obama changed the name to African American Music Heritage Month and in 2023, Pres. Joe Biden changed it back to Black Music Month, two years after he declared Juneteenth a national holiday, the result of a movement led by Opal Lee.

Our ancestors battle for freedom over these last 400 years and the music that allowed them expression of their humanity deserved to be honored.

But we may be losing sight of the value of their sacrifices.

‘Sing a Song Full of the Faith That the Dark past Has Taught Us…’

Along with the long-known exploitation of Black musicians whose recordings were stolen by record companies, the commercialization of Juneteenth feels like another kind of theft.

I had never heard of Juneteenth until I moved to the Bay Area from my hometown of Philadelphia. I didn’t know it was one of many freedom festivals celebrated by descendants of enslaved people in the United States.

Emancipation Day was Jan. 1 in Pennsylvania, April 16 in Wash., D.C., May 20 in Florida, and Aug. 8 in Kentucky. But Juneteenth, June 19, has the most renown, known in Texas as the ‘colored peoples’ Fourth of July.’

It was marked by parades, beauty pageants, rodeos, backyard barbecues and church picnics.

Yes, church.

The formerly enslaved began the day praying in thanks for their freedom just as they had prayed for Jubilee – the day of freedom – when they had chains on their feet and hands. They ‘testified’ about their past suffering and how they had managed to overcome.

And they sang.

Although, we will not hold it this year, Omnira Institute’s Juneteenth Ritual of Remembrance recalled this part of Juneteenth with prayers in the languages of the African captives. In the middle of the ceremony, a soloist would lead us in singing “Many Thousand Gone” while we took turns reciting portions of the Emancipation Proclamation, the news of freedom that took more than two years to reach Texas – two months after the Civil War ended.

“Many Thousand Gone” was famously recorded by Black luminary Paul Robeson in 1947:

“No more auction block for me,

No more, no more

No more auction black for me

Many thousand gone.”

Other verses refer to the ‘pint of salt’ and the ‘driver’s lash,’ the realities of enslavement that they had survived.

‘Sing a Song Full of the Hope That the Present has Brought Us’

All of the genres of African American music have at their root songs like that, the essence being, as Stevie Wonder, wrote, “the joy inside our pain.” So Black music is not just music. It is our story, our history, our very strength.

During the Civil Rights Movement, which peaked 100 years after slavery ended, the people testified that it was the freedom songs – based on spirituals – that gave them the heart to march, face attack dogs, fire hoses, beatings, and shootouts with vigilantes.

The music reminded them that power was in the people. That music, our music, can do so again. We don’t have to accept the commodification of the products of our culture.

The power of those songs is showing a resurgence across the South as we battle again for the right to self-determination through the ballot box.

Those songs are the voices of our ancestors, voices forged in their blood, their sweat, their tears, joy and, above all, faith.  Those songs, those prayers live in our blood and our very breath.

This Juneteenth, let us reclaim those holy voices expressed in Black music for ourselves. It is our birthright. It can neither be bought nor sold.  No more. Never again.

Wanda Ravernell is the executive director of Omnira Institute, sponsor for 18 years of the Juneteenth Ritual of Remembrance and Oakland’s 11th Annual Black-Eyed Pea Festival, which will take place on Sept. 12.

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Activism

Oakland Post: Week of June 3 – 9, 2026

The printed Weekly Edition of the Oakland Post: Week of June 3 – 9, 2026

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Study: Waiting Lists for Child Care Assistance Nearly Doubled

BLACKPRESS USA NEWSWIRE — “Since the expiration of tens of billions of dollars in federal child care funding in 2023 and 2024, an already fragile child care system has been pushed even closer to the brink.”
The post Study: Waiting Lists for Child Care Assistance Nearly Doubled appeared first on BlackPressUSA.

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By National Women’s Law Center

The National Women’s Law Center released its annual State Child Care Assistance Policies report, finding that the number of children placed on waiting lists for federally funded child care assistance nearly doubled between 2024 and 2025 — and that number has only continued to grow.

The report serves as a key resource for state lawmakers, advocates, and policymakers by tracking state child care assistance policies and identifying where states are strengthening support for families and early educators — or falling behind.

“This deeply troubling increase in the number of children on child care waiting lists is the result of a failure to invest in this crucial sector,” said Karen Schulman, senior director of state child care policy and author of the report. “Since the expiration of tens of billions of dollars in federal child care funding in 2023 and 2024, an already fragile child care system has been pushed even closer to the brink.”

Key findings in the report related to waiting lists for child care assistance include:

• 17 states had waiting lists or a freeze on intake for child care assistance in February 2025, up from 13 states in February 2024.

• Approximately 106,700 children nationwide were added to waiting lists between February 2024 and February 2025, bringing the total to 225,500 children in February 2025 — a 90 percent increase compared to February 2024.

• The numbers climbed even further between February 2025 and summer/fall 2025, with more than 175,000 additional children added to state waiting lists in just a few months — a 78 percent increase.

• At least seven states newly began placing families on waiting lists or freezing intake, while at least 10 additional states saw their waiting lists grow, after February 2025.

The report also includes state-by-state data on key child care assistance policies, including income eligibility limits, parent copayments, provider payment rates, and eligibility policies for parents searching for work.

Click the link to learn more: Warning Signs: State Child Care Assistance Policies 2025.

The post Study: Waiting Lists for Child Care Assistance Nearly Doubled appeared first on BlackPressUSA.

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